Research Areas
Early Detection of Strokes
Stroke is a devastating disease that claims more than 500,000 lives in the world every year. If we can identify high risk patients before a stroke happens, we will be able to reduce the number of deaths and save more lives. In this work, our team develops an AI-based stress test to predict potential strokes.
Brain Development in the First Two Decades of Life
The first two decades of life are critical to the human brain development. Our team aims to establish important milestones in different stages of brain development using MR images of children's brains.
Treatment Outcome Predictions
Artificial intelligence can be leveraged to predict treatment outcomes for patients with brain diseases. By combining clinical, genetic, imaging, and behavioral data, our team aims to develop AI algorithms that provide personalized insights for patients.
Publications
Recommendations for Quantitative Cerebral Perfusion MRI Using Multi-timepoint Arterial Spin Labeling: Acquisition, Quantification, and Clinical Applications
by Joseph G. Woods, Eric Achten, Iris Asllani, Divya S. Bolar, Weiying Dai, John A. Detre, Audrey P. Fan, María A. Fernández-Seara, Xavier Golay, Matthias Günther, Jia Guo, Luis Hernandez-Garcia, Mai-Lan Ho, Meher R. Juttukonda, Hanzhang Lu, Bradley J. MacIntosh, Ananth J. Madhuranthakam, Henk-Jan Mutsaerts, Thomas W. Okell, Laura M. Parkes, Nandor Pinter, Joana Pinto, Qin Qin, Marion Smits, Yuriko Suzuki, David L. Thomas, Matthias J. P. Van Osch, Danny J. J. Wang, Esther A.H. Warnert, Greg Zaharchuk, Fernando Zelaya, Moss Zhao, Michael A. Chappell, on behalf of the ISMRM Perfusion Study Group, (Apr, 2024)
DOI: mrm.30091
Reproducibility of Arterial Spin Labeling Cerebral Blood Flow Image Processing: A Report of the ISMRM Open Science Initiative for Perfusion Imaging (OSIPI) and the ASL MRI Challenge
by Andre M. Paschoal, Joseph G.Woods, Joana Pinto, Esther E. Bron, Jan Petr, Flora A. Kennedy McConnell, Laura Bell, Maria-Eleni Dounavi, Cassandra Gould van Praag, Henk J. M. M. Mutsaerts, Aaron Oliver Taylor, Moss Y. Zhao, Irène Brumer, Wei Siang Marcus Chan, Jack Toner, Jian Hu, Logan X. Zhang, Catarina Domingos, Sara P. Monteiro, Patrícia Figueiredo, Alexander G. J. Harms6 Beatriz E. Padrela, Channelle Tham, Ahmed Abdalle, Paula L. Croal, Udunna Anazodo (2024)
DOI: 10.1002/mrm.30081
DOI: 10.1002/mrm.30081
Turning Brain MRI into Diagnostic PET: 15O-water PET CBF Synthesis from Multi-contrast MRI via Attention-based Encoder–decoder Networks
by Ramy Hussein, David Shin, Moss Y Zhao, Jia Guo, Guido Davidzon, Gary Steinberg, Michael Moseley, Greg Zaharchuk (2024)
DOI: 10.1016/j.media.2023.103072
DOI: 10.1016/j.media.2023.103072
BASIL: A Toolbox for Perfusion Quantification using Arterial Spin Labelling
by Michael A. Chappell, Thomas F. Kirk, Martin S. Craig, Flora A. Kennedy McConnell, Moss Y. Zhao, Bradley J. MacIntosh, Thomas W. Okell, Mark W. Woolrich (2023)
DOI: 10.1162/imag_a_00041
Early-Frame [18F]Florbetaben PET/MRI for Cerebral Blood Flow Quantification in Patients with Cognitive Impairment: Comparison to an [15O]Water Gold Standard
by Ates Fettahoglu, Moss Y, Zhao, Mehdi Khalighi, Hillary Vossler, Maria Jovin, Guido Davidzon, Michael Zeineh, Fernando Boada, Elizabeth Mormino, Victor W. Henderson, Michael Moseley, Kevin T. Chen and Greg Zaharchuk (2023)
DOI: 10.2967/jnumed.123.266273
DOI: 10.2967/jnumed.123.266273
Segmenting Cervical Arteries in Phase Contrast Magnetic Resonance Imaging Using Convolutional Encoder–Decoder Networks
by Britney Campbell, Dhruv Yadav, Ramy Hussein, Maria Jovin, Sierrah Hoover, Kim Halbert, Dawn Holley, Mehdi Khalighi, Guido A. Davidzon, Elizabeth Tong, Gary K. Steinberg, Michael Moseley, Moss Y. Zhao, Greg Zaharchuk (2023)
DOI: 10.3390/app132111820
DOI: 10.3390/app132111820
Editorial for “Altered Brain Function in Pediatric Patients With Complete Spinal Cord Injury: A Resting-State Functional MRI Study”
by Rui Duarte Armindo, Moss Y Zhao (2023)
DOI: 10.1002/jmri.29085
Short- and Long-Term MRI Assessed Hemodynamic Changes in Pediatric Moyamoya Patients After Revascularization
by Moss Y. Zhao, Elizabeth Tong, Rui Duarte Armindo, Ates Fettahoglu BSc, Jason Choi, Jacob Bagley, Kristen W. Yeom, Michael Moseley, Gary K. Steinberg, Greg Zaharchuk (2018)
DOI: 10.1002/jmri.28902
DOI: 10.1002/jmri.28902
Longitudinal Alterations of Cerebral Blood Flow in High-Contact Sports
by Mahta Karimpoor, Marios Georgiadis, Moss Y. Zhao, Maged Goubran, Hossein Moein Taghavi, Brian D. Mills, Dean Tran, Nicole Mouchawar, Sohrab Sami, Max Wintermark, Gerald Grant, David B. Camarillo, Michael E. Moseley, Greg Zaharchuk, Michael M. Zeineh (2023)
DOI: 10.1002/ana.26718
DOI: 10.1002/ana.26718
Measuring Quantitative Cerebral Blood Flow in Healthy Children: A Systematic Review of Neuroimaging Techniques
Moss Y. Zhao, Elizabeth Tong, Rui Duarte Armindo, Amanda Woodward, Kristen W Yeom, Michael Moseley, Greg Zaharchuk (2023)
DOI: 10.1002/jmri.28758
Effect of Vitamin D Supplementation on Cerebral Blood Flow in Male Patients with Adrenoleukodystrophy
Moss Y. Zhao, Alex Dahlen, Norma Jimenez Ramirez, Michael Moseley, Keith Van Haren, Greg Zaharchuk (2023)
DOI: 10.1002/jnr.25187
DOI: 10.1002/jnr.25187
Advanced MR Techniques for Preoperative Glioma Characterization: Part 2
Gilbert Hangel, Bárbara Schmitz-Abecassis, Nico Sollmann, Joana Pinto, Fatemehsadat Arzanforoosh, Frederik Barkhof, Thomas Booth, Marta Calvo-Imirizaldu, Guilherme Cassia, Marek Chmelik, Patricia Clement, Ece Ercan, Maria A. Fernández-Seara, Julia Furtner, Elies Fuster-Garcia, Matthew Grech-Sollars, N. Tugay Guven, Gokce Hale Hatay, Golestan Karami, Vera C. Keil, Mina Kim, Johan A. F. Koekkoek, Simran Kukran, Laura Mancini, Ruben Emanuel Nechifor, Alpay Özcan, Esin Ozturk-Isik, Senol Piskin, Kathleen M. Schmainda, Siri F. Svensson, Chih-Hsien Tseng, Saritha Unnikrishnan, Frans Vos, Esther Warnert, Moss Y. Zhao, Radim Jancalek, Teresa Nunes MD, PhD, Lydiane Hirschler, Marion Smits, Jan Petr, Kyrre E. Emblem (2023)
DOI: 10.1002/jmri.28663
DOI: 10.1002/jmri.28663
Advanced MR Techniques for Preoperative Glioma Characterization: Part 1
by Lydiane Hirschler, Nico Sollmann, Bárbara Schmitz-Abecassis, Joana Pinto, Fatemehsadat Arzanforoosh, Frederik Barkhof, Thomas Booth, Marta Calvo-Imirizaldu, Guilherme Cassia, Marek Chmelik, Patricia Clement, Ece Ercan, Maria A. Fernández-Seara, Julia Furtner, Elies Fuster-Garcia, Matthew Grech-Sollars, Nazmiye Tugay Guven, Gokce Hale Hatay, Golestan Karami, Vera C. Keil, Mina Kim, Johan A. F. Koekkoek, Simran Kukran, Laura Mancini, Ruben Emanuel Nechifor, Alpay Özcan, Esin Ozturk-Isik, Senol Piskin, Kathleen Schmainda, Siri F. Svensson, Chih-Hsien Tseng, Saritha Unnikrishnan, Frans Vos, Esther Warnert, Moss Y. Zhao, Radim Jancalek, Teresa Nunes, Kyrre E. Emblem, Marion Smits, Jan Petr, Gilbert Hangel (2023)
DOI: 10.1002/jmri.28662
Revascularization Improves Vascular Hemodynamics − A Study Assessing Cerebrovascular Reserve and Transit Time in Moyamoya Patients using MRI
by Moss Y Zhao, Rui Duarte Armindo, Andrew J Gauden, Benjamin Yim, Elizabeth Tong, Michael Moseley, Gary K Steinberg, Greg Zaharchuk (2022)
DOI: 10.1177/0271678X221140343
DOI: 10.1177/0271678X221140343
Recent Technical Developments in ASL: A Review of the State of the Art
by Luis Hernandez-Garcia, Veronica Aramendia-Vidaurreta, Divya S. Bolar, Weiying Dai, Maria A. Fernández-Seara, Jia Guo, Ananth J. Madhuranthakam, Henk Mutsaerts, Jan Petr, Qin Qin, Jonas Schollenberger, Yuriko Suzuki, Manuel Taso, David L. Thomas, Matthias J. P. van Osch, Joseph Woods, Lirong Yan, Ze Wang, Li Zhao, Moss Y. Zhao, Thomas W. Okell (2022)
DOI: 10.1002/mrm.29381
DOI: 10.1002/mrm.29381
Recent Technical Developments in ASL: A Review of the State of the Art
by Luis Hernandez-Garcia, Veronica Aramendia-Vidaurreta, Divya S. Bolar, Weiying Dai, Maria A. Fernández-Seara, Jia Guo, Ananth J. Madhuranthakam, Henk Mutsaerts, Jan Petr, Qin Qin, Jonas Schollenberger, Yuriko Suzuki, Manuel Taso, David L. Thomas, Matthias J. P. van Osch, Joseph Woods, Lirong Yan, Ze Wang, Li Zhao, Moss Y. Zhao, Thomas W. Okell (2022)
DOI: 10.1002/mrm.29381
Velocity-selective Arterial Spin Labeling Perfusion MRI: A Review of the State of the Art and Recommendations for Clinical Implementation
by Qin Qin, David C. Alsop, Divya S. Bolar, Luis Hernandez-Garcia, James Meakin ,Dapeng Liu, Krishna S. Nayak, Sophie Schmid, Matthias J. P. van Osch, Eric C. Wong,Joseph G. Woods, Greg Zaharchuk, Moss Y. Zhao, Zungho Zun, Jia Guo (2022)
DOI: 10.1002/mrm.29371
DOI: 10.1002/mrm.29371
Using Arterial Spin Labeling to Measure Cerebrovascular Reactivity in Moyamoya Disease: Insights from Simultaneous PET/MRI
by Moss Y Zhao, Audrey P Fan, David Yen-Ting Chen, Yosuke Ishii, Mohammad Mehdi Khalighi, Michael Moseley, Gary K Steinberg, Greg Zaharchuk (2022)
DOI: 10.1177/0271678X221083471
DOI: 10.1177/0271678X221083471
Reliability of arterial spin labeling derived cerebral blood flow in periventricular white matter
by Sudipto Dolui, Audrey P.Fan, Moss Y. Zhao, Ilya M. Nasrallah Greg Zaharchuk, John A. Detre (2021)
DOI: 10.1016/j.ynirp.2021.100063
Reproducibility of cerebrovascular reactivity measurements: A systematic review of neuroimaging techniques.
by Moss Y Zhao, Amanda Woodward, Audrey P Fan, Kevin T Chen, Yannan Yu, David Y Chen, Michael E Moseley, Greg Zaharchuk (2021)
DOI: 10.1177/0271678X211056702
DOI: 10.1177/0271678X211056702
Cerebrovascular Reactivity Measurements Using Simultaneous 15O-Water PET and ASL MRI: Impacts of Arterial Transit Time, Labeling Efficiency, and Hematocrit.
by Moss Y Zhao, Audrey P Fan, David Yen-Ting Chen, Magdalena J. Sokolska, Jia Guo, Yosuke Ishii, David D Shin, Mohammad Mehdi Khalighi, Dawn Holley, Kim Halbert, Andrea Otte, Brittney Williams Taghi Rostami, Jun-Hyung Park, Bin Shen, Greg Zaharchuk (2021)
DOI: 10.1016/j.neuroimage.2021.117955
DOI: 10.1016/j.neuroimage.2021.117955
Predicting PET Cerebrovascular Reserve with Deep Learning by Using Baseline MRI: A Pilot Investigation of a Drug-Free Brain Stress Test
by David Y. T. Chen, Yosuke Ishii, Audrey P. Fan, Jia Guo, Moss Y. Zhao, Gary K. Steinberg, Greg Zaharchuk (2020)
DOI:10.1148/radiol.2020192793
Quantification of cerebral perfusion and cerebrovascular reserve using Turbo-QUASAR arterial spin labeling MRI
by Moss Y. Zhao, Lena Václavů, Esben T. Petersen, Bart J. Biemond, Magdalena J. Sokolska, Yuriko Suzuki, David L. Thomas, Aart J. Nederveen, Michael A. Chappell (2019)
DOI: 10.1002/mrm.27956
DOI: 10.1002/mrm.27956
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